Leukemic phase of anaplastic lymphoma kinase positive, anaplastic large cell lymphoma

Leukemic phase of ALK-positive anaplastic large cell lymphoma.

A 25-year-old woman presented with lymphadenopathy. Peripheral blood showed leukocytosis, anemia, and thrombocytopenia (white blood cell count, 102.9 3 10/L; hemoglobin level, 76 g/L; and platelet count, 32 3 10/L). Peripheral smear demonstrated a predominant population of large cells with reticular chromatin, folded to irregular nuclear contours, and abundant basophilic cytoplasm. Many cells c...

Leukemic manifestation of anaplastic lymphoma kinase-negative-type anaplastic large-cell lymphoma

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 53-year-old woman had multiple bilateral axillary and left supraclavicular lymph-node (LN) enlargements for 6 months. LN biopsy revealed anaplastic large-cell lymphoma (ALCL) that was anaplastic lymphoma kinase (ALK)-negative (A. typical " hallmark " cell:...

Primary gastric anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma

INTRODUCTION Most primary stomach lymphomas are now recognized to originate from B-cell. Primary gastric anaplastic lymphoma kinase (ALK)-negative anaplastic large-cell lymphoma (ALCL) as shown in this case is very rare. CASE REPORT A 59-year-old man presented with a 1-month history of epigastric pain. Computed tomography showed a tumor in the stomach with perigastric lymphadenopathy. Biopsy ...

ALK- negative Anaplastic Large Cell Lymphoma of Bone

Leukemic transformation of anaplastic large-cell lymphoma.

A 9-year-old boy was diagnosed with stage III ALK-positive anaplastic large cell lymphoma (ALCL) with no evidence of bone marrow and central nervous system disease. Seven months later he had a normocytic anemia (hemoglobin 79 g/L), severe thrombocytopenia (platelets 15 109/L), and leukocytosis (white blood cell count 50.8 109/L). The automated differential showed neutrophils 28.5 109/L, monocyt...